“Genomic Perfection” Versus “Cellular Survival”
cell, cellular survival, cleaning robots, DNA, DNA integrity, DNA lesion, DNA repair, environmental mutagens, genome, genomic perfection, Intelligent Design, mutations, passenger mutations, quality control mechanisms, Science (journal), WALL-E
Here is a thought-provoking hypothesis in this week’s Science about “genomic perfection” versus “cellular survival.” From “Cellular survival over genomic perfection“ (open access): The high number of passenger mutations, equivalent to 1000 to 10,000 per genome, in normal cells raises questions regarding why DNA quality control mechanisms have failed to limit mutagenesis. Perhaps a somewhat counterintuitive perspective can be considered: If DNA quality control pathways monitor and preserve DNA integrity too strictly, it could be detrimental to cellular survival. The repair of DNA lesions has a cost: It requires time and cellular resources. If every DNA lesion in a cell were repaired, avoiding mutations altogether, the cellular cost associated with performing that repair would have to increase in direct proportion to the amount of damage. In conditions of high DNA damage — through exposure to…