Important Medical Effects but Modest Mutations
Charles Darwin, CypA, Darwin Devolves, Darwinian processes, Evolution, FCT, function, Functional-Coded-elemenT, HIV, information, isoform, natural selection, New Scientist, Origin of Species, owl monkey, protein, random mutation, retroviruses, rhesus macaque, RNA, The Quarterly Review of Biology, TRIM5
I was asked to address a comment left by a viewer of one of Discovery’s YouTube videos. The comment is:1 Some monkeys have a mutation in a protein called TRIM5 that results in a piece of another, defunct protein being tacked onto TRIM5. The result is a hybrid protein called TRIM5-CypA, which can protect cells from infection with retroviruses such as HIV. Here, a single mutation has resulted in a new protein with a new and potentially vital function. New protein, new function, new information. A bit of Googling shows that the text was taken word-for-word from an old article (2008) on the New Scientist website2 (perhaps by way of intermediate copying). That was during a period when the 150th anniversary of the publication of the Origin of Species was…