How Irreducible Complexity Can Help with Cancer Drug Research

AlphaFold3, apoptosis, bioinformatic data, cancer, cancer cells, carboxy-terminal domain, cell death, cell's, chemotherapy, chromatin, Darwin's Black Box, DNA, DNA replication, double helix, enzymes, Freed-Hardeman University, Intelligent Design, intrinsically disordered regions, Irreducible Complexity, isoforms, Joe Deweese, Medicine, mutants, proteins, replication, TOP2A, TOP2B, topoisomerases, toxic side effects
Topoisomerases are molecular machines that play a critical role in resolving DNA tangles and supercoiling generated during DNA replication. Source
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It Turns Out Disorder Is Functionally Important

AlphaFold2 Multimer, binding, biology, disorder, Drosophila melanogaster, genetics, interactome, intrinsic disorder, intrinsically disordered regions, Junhui Peng, Li Zhao, orphan genes, PLOS Computational Biology, protein-protein interactions, proteins, Rockefeller University, taxonomically restricted genes
Li Zhao of Rockefeller University is a leading investigator on the origin and function of orphan and taxonomically restricted genes (TRGs) and proteins. Source
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