How Do Mitotic Errors Affect Cell Proliferation?

anaphase, aneuploidy, biology, biologyu, cancer, cancer cells, cell fusion, cell proliferation, cell's, chromatids, chromosomal instability, chromosome, chromosome missegregation, cohesin ring, cytokinesis failure, DNA, E-Cadherin, endoreduplication, eukaryotic cell cycle, Evolution, intelligent cause, Intelligent Design, Irreducible Complexity, kinetochore, Medicine, micronuclei, mitotic cell division, mitotic spindle, oocytes, proteasome, securin, separase, spindle assembly checkpoint, tetraploidization, tetraploidy, tumorigenesis, tumors
This review furthers the argument that I have developed elsewhere that the eukaryotic cell division cycle is elegantly engineered and irreducibly complex. Source
Read More

The Eukaryotic Cell Cycle: An Irreducibly Complex System

anaphase, ATPase, aurora kinases, BIO-Complexity, cell division, centromere, checkpoints, chromosomal disorganization, chromosome, chromosome segregation, condensins, contractile ring, dynein, Engineering, eukaryotic cell cycle, eukaryotic cell division, Evolution, foresight, Intelligent Design, irreducibly complex, kinesin, kinetochore, Maintenance of Chromosomes, metaphase, microtubules, mitosis, mitotic cell division, motor proteins, protein complexes, proteins, spindle formation, ubiquitylate securin
Any system that achieves a complex higher-level objective by means of various well-matched interacting components requires foresight to come about. Source
Read More

Engineered Elegance: Generating the Wait Anaphase Signal

anaphase, aneuploidy, cancer, chromatid pairs, chromosomal instability, chromosomes, colon cells, developmental abnormalities, Down syndrome, inhibitory complexes, Intelligent Design, kinetochores, Medicine, metaphase, microtubules, mitotic spindle, phosphatase, prometaphase, safety belt, spindle assembly checkpoint, tumorigenesis, tumors, yeast
Even a single unattached kinetochore is sufficient to trigger the wait anaphase signal, which inhibits activation of the APC/C that drives entry into anaphase. Source
Read More