Just-in-Time Delivery in Living Cells
Amazon, cardiovascular disease, cell's, coronavirus, cryo-electron microscope, delivery, endosomes, enzymes, FedEx, HSPG, Intelligent Design, Lauren Jackson, lipoprotein lipase, LPL, male haploid genome, Max Planck Institute, NEDD8, nexins, PNAS, ribosomes, SDC1, sex, shipping, sperm, Structure (journal), syndecan-1, trash, triglycerides, truckers, U.C. San Diego, U.S. Postal Service, ubiquitin, UPS, Vanderbilt University, vesicles
During the coronavirus crisis, truckers have played an essential role in getting masks, medicines, and equipment to hospitals that were overwhelmed, and food to the grocery stores to prevent a starvation crisis as people obeyed stay-at-home orders. Some of the truckers drove long all-night shifts to meet the critical demand. Non-essential deliveries of goods from retail merchants like Amazon continued mostly uninterrupted, too. Human delivery systems rely on distributed storage. Cells know all about this. A cell is a large place, like a city to the molecules inside; it is inefficient to store needed cargoes far from their work sites. Within the cell, highways of microtubules grow in the directions that cargo carriers like kinesins need them. Some new discoveries show that additional mechanisms supplement those well-known processes to provide…