Could Genetic Mutations Be Non-Random? New Evidence for Mutational Bias

Africa, African sleeping sickness, APOL1, Daniel Melamed, diseases, Engineering, Evolution, genes, genetic mutations, genetics, genomes, germline genome, haploid, heterozygotes, HindIII, homozygotes, Intelligent Design, Israel, malaria, MEMDS, mutation DNA, Mutation Enrichment followed by Maximum Depth Sequencing, mutation frequency, mutations, Proceedings of the National Academy of Sciences, randomness, restriction enzyme, sperm, sperm DNA, Trypanosoma brucei, University of Haifa, wild-type DNA
The researchers examined the emergence of a mutation in the human APOL1 gene that confers protection from African sleeping sickness. Source
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Sexual Reproduction: Engineered for Success

Bayesian reasoning, Charles Darwin, Darwin's Black Box, egg, Engineering, Evolution, evolutionary theory, fertilization, forethought, goal, human reproduction, ID The Future, Intelligent Design, Irreducible Complexity, irreducibly complex systems, Jonathan McLatchie, Michael Behe, natural selection, Podcast, purpose, seminal fluid, sexual reproduction, sperm, sperm capacitation
I continue a three-part discussion with Dr. Jonathan McLatchie on why sex is the queen of problems for evolutionary theory. Source
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Remembering Bernie Widrow, a Great Engineer and a Wise Scientist

ADALINE, Adolf Hitler, algorithms, Artificial Intelligence, Bell Labs, Bernard Widrow, Boeing, Claude Shannon, Computational Sciences, copper, copper plating, Earl Sannard Herald, electrical engineering, electroplating, Engineering, English, Frank Rosenblatt, French, IEEE Alexander Graham Bell Medal, IEEE Neural Networks Pioneer Medal, Japanese, Least Mean Squares, MADALINE, Marcian Hoff, National Academy of Engineering, Neural Networks, neurons, pennies, Science in Action, Seattle, silver nitrate, speech recognition, Stanford University
Widrow called his learning machine a neural network because it was loosely based on the 1943 McCulloch-Pitts model of the biological neuron. Source
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Systems Biology and Intelligent Design: A Natural Fit

AmiGO, biological networks, biology, computers, coordination, Darwinian evolution, data networks, datasets, E. coli, Engineering, Gene Ontology, genomics, glycolysis, Intelligent Design, Introduction to Systems Biology, isoforms, Joel Bader, Junk DNA, living systems, long non-coding RNAs, metabolomics, molecular biology, Molecular Systems Biology, mRNA, mutations, optimal design, optimism, proteins, proteomics, reductionist biology, Rube Goldberg, Ruedi Aebersold, smartphones, Systems Biology, Technology, transcription network, transcriptomics, Uri Alon, Yuri Lazebnik
In December 2025, Molecular Systems Biology marked its 20th anniversary with a special editorial that reflects on the field’s development since 2005 (Bheda et al. 2025). Systems biology is an approach to studying living systems that assumes hierarchical, top-down design. The piece, authored by the journal’s editors and several contributors, shares personal perspectives on where the field stands today — and where it is headed. Ruedi Aebersold, the first contributor, states, “the first 20 years of MSB were grand; the next 20 years will be grander.”  I too am optimistic about the field’s future. My optimism comes specifically from how powerfully top-down design has succeeded in giving us the complex systems of the modern world. Top-down design prunes the vast search space of possibilities through an Read More › Source
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Casey Luskin on the Rising Tide of Intelligent Design Research

biological features, biological traits, body plans, Casey Luskin, Christmas, common ancestry, complex parts, discoveries, Engineering, Evolution, evolutionary biology, functionality, genome, genome sequencing, ID The Future, Intelligent Design, Junk DNA, Neo-Darwinism, organs, origin of life, orphan genes, predictions, purpose, Research, teleology, tide, trees of life, universe
Any scientific theory for the origin of life and the universe is only as strong as its research program. For intelligent design, this is good news. Source
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Year in Review: Demonstrating the Power of the Intelligent Design Framework in Biology

anatomy, biologists, biology, biomimicry, blood flow, brain, CELS, Conference on Engineering in Living Systems, design reuse, Emily Reeves, Engineering, Engineering Research Group, engineers, genetic profiles, genetic variation, genome architecture, Gerald Fudge, glycolysis, Intelligent Design, James Clayton Prize, James Johansen, living systems, Macroevolution, Michael Egnor, Microevolution, modularity, optimality, pathology, physicians, physiology, Research, robustness, Stuart Burgess, systems engineering, Texas A&M, theory of biological design, Windkessel
Our scientists and engineers have further laid the foundation for a comprehensive and actionable theory of biological design. Source
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Tiled Beauty: Functional Aesthetics in Biology

architecture, armadillos, arthropods, beauty, beehive, beeswax, biodiversity, biology, Biomimetics, butterfly wings, classification, compound eyes, Darwinism, design, Engineering, Evolution, False Messiah, function, functional needs, German Research Foundation, Gothic cathedrals, honeycomb, Intelligent Design, Jana Ciecierska-Holmes, Linnaean taxonomy, multifunctionality, Neil Thomas, phylogeny, PNAS Nexus, reptiles, scales, sunflowers, tessellated patterns, tessellation, tile shapes, tiles, tortoise shell
Tessellated patterns are surprisingly prevalent in biology. Are these forms necessary for function, or mere consequences of natural laws?  Source
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Robert Marks Remembers ID and Tech Pioneer Walter Bradley

Baylor University, car mats, Charles Thaxton, chemical evolution, coconuts, Colorado School of Mines, Dignity Coconuts, Discovery Institute, Douglas Axe, Engineering, Evolution, Intelligent Design, Jay Richards, materials, mosquitoes, origin of life, Philippines, Robert J. Marks II, Roger Olsen, Stephen Meyer, Technology, Texas A&M University, The Mystery of Life’s Origin, Walter Bradley, weapons, William Dembski
In 1984, three scientists dared to probe the mystery of life’s origin by putting the prevailing theories of prebiotic and chemical evolution to the test. Source
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Living in 3-D: Not a Big Deal? New Video Explains Why It’s a VERY Big Deal

astigmatism, athletes, awareness, body parts, cars, consciousness, cornea, curvature, emergence, Engineering, eyeglasses, headlights, hearing, Howard Glicksman, Intelligent Design, lens, prescription, proprioception, purpose, routine tasks, Secrets of the Human Body, Steve Laufmann, street, three dimensions, vision, walking, Your Amazing Body
Living in three dimensions is crucial not only for athletes, who excel at exploiting the body’s abilities, but for any one of us walking down the street. Source
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