“Genomic Perfection” Versus “Cellular Survival”

cell, cellular survival, cleaning robots, DNA, DNA integrity, DNA lesion, DNA repair, environmental mutagens, genome, genomic perfection, Intelligent Design, mutations, passenger mutations, quality control mechanisms, Science (journal), WALL-E
Here is a thought-provoking hypothesis in this week’s Science about “genomic perfection” versus “cellular survival.” From “Cellular survival over genomic perfection“ (open access): The high number of passenger mutations, equivalent to 1000 to 10,000 per genome, in normal cells raises questions regarding why DNA quality control mechanisms have failed to limit mutagenesis. Perhaps a somewhat counterintuitive perspective can be considered: If DNA quality control pathways monitor and preserve DNA integrity too strictly, it could be detrimental to cellular survival. The repair of DNA lesions has a cost: It requires time and cellular resources. If every DNA lesion in a cell were repaired, avoiding mutations altogether, the cellular cost associated with performing that repair would have to increase in direct proportion to the amount of damage. In conditions of high DNA damage — through exposure to…
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Memorial Symposium for Phillip Johnson

Center for Science & Culture, Discovery Institute, Douglas Axe, First Presbyterian Church of Berkeley, Intelligent Design, Jonathan Wells, Michael Behe, Paul Nelson, Phillip E. Johnson, scholars, scientists, Stephen Meyer, U.C. Berkeley
Following a private memorial service on November 23, Discovery Institute is pleased to host a brief public symposium in honor of the late Phillip E. Johnson — U.C. Berkeley law professor and Center for Science & Culture program advisor, who passed away earlier this month. You are invited to join us at the First Presbyterian Church of Berkeley from 4:00–5:30 pm on Saturday, November 23, to hear brief (10–15 minute) tributes from intelligent design scientists and scholars who have been directly impacted by Phil’s life and have since become the ID torch-bearers for our generation. Among those speaking will be Stephen Meyer, Michael Behe, Jonathan Wells, Douglas Axe, Paul Nelson, and others. The presenters will share their unique perspectives on the impact of Phil’s work and subsequent growth of the ID research program in their respective fields of research. There is no…
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